第四章；《挣脱枷锁的恶疾》的结尾，体型庞大的女反派（萨哈拉·赫克斯利饰）决定同时挑战四位女英雄。黛西·链（斯泰西·伯克饰）用她的雏菊圆盘将恶疾束缚起来，旭日（安吉拉·萨默斯饰）启动了她的太阳能量，棱镜（朱厄尔·玛索饰）则点燃了她戒指的能量。尽管如此强大的力量都倾泻在恶疾身上，指南针（金伯利·简饰）却发现这个邪恶的威胁竟然在微笑。一股不可思议的力量爆发，恶疾挣脱了束缚——女战士们即将迎来一场前所未有的惨败。这是漫画巨星乔治·佩雷斯带来的又一部精彩绝伦的“超级女英雄姐妹会”作品！
Chapter Four; The conclusion of UNCHAINED MALADY finds the hulking titular villainess (Saharra Huxly) deciding to take on all four heroines at once. As Daisy Chain (Stacy Burke) uses her daisy disc to bind Malady with chains, Sunburst (Angela Sommers) fires up her solar powers while Prism (Jewell Marceau) ignites her ring’s energy. Even with all this power being hurled at the ominous ogress, Compass (Kymberly Jane) notices that the malevolent menace is actually smiling. In a burst of unbelievable power, Malady breaks out of her chains–and the superheroines are in for the beating of a lifetime. Another Sisterhood of Superheroines spectacular from comic book superstar George Pérez!